P-glycoprotein Inhibition for Optimal Drug Delivery
نویسندگان
چکیده
منابع مشابه
P-glycoprotein Inhibition for Optimal Drug Delivery
P-glycoprotein (P-gp), an efflux membrane transporter, is widely distributed throughout the body and is responsible for limiting cellular uptake and the distribution of xenobiotics and toxic substances. Hundreds of structurally diverse therapeutic agents are substrates to it and it impedes the absorption, permeability, and retention of the drugs, extruding them out of the cells. It is overexpre...
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ژورنال
عنوان ژورنال: Drug Target Insights
سال: 2013
ISSN: 1177-3928,1177-3928
DOI: 10.4137/dti.s12519